Study the neuroprotective effect of tyrosol in an experimental model of huntington's disease as a subsidy for the development of new medicines

Resumo

The increase in the elderly population has led to an increasing incidence of neurodegenerative diseases worldwide. This has provided a keen interest in studies aimed at new strategies for the prevention and cure of diseases. Huntington's disease (hd) is an autosomal dominant neurodegenerative disorder characterized by involuntary choreiform movements, emotional disturbances and dementia .the 3-nitropropionic acid (3-np) is an irreversible inhibitor of succinate dehydrogenase enzyme complex ii of the respiratory chain provoked alterations similar to hd. The tyrosol is a phenolic compound that is present in olive oil and wine, it is known as a potent antioxidant and anti-inflammatory.  “(a) objectives tyrosol can exert neuroprotection on behavioral and biochemical against oxidative stress induced by 3-np”, “(b) materials and methods adult rats were treated by gavage with tyrosol (3-15mg/kg) or vehicle 1h before 3-np for 7 consecutive days. Behavioral parameters were analyzed using open field, rotarod and elevated plus maze test. Lipoperoxidation in the nigroestriatal system and cerebral cortex were also evaluated.”, “(c) results the tyrosol at doses of 10 and 15 mg/kg, was able to improve the behavioral and biochemical parameters of hd induced by 3np.” And “(d) conclusion the tyrosol has an effective protection of neurons against huntington's disease.”