Non-clinical and pre-clinical pharmacological investigations of Mimosa diplotricha

Resumo

The present study aims to screen pharmacological and phytochemical screenings of the Mimosa diplotricha. For this the ethanolic crude extract of M. diplotricha (EMd) was undergone for checking antioxidant, anti-inflammatory and membrane stabilizing, anti-diarrheal and clotlysis activities followed by a preliminary phytochemical screening. Results suggest that, the EMd concentration-dependently exhibited antiradical (DPPH: 1,1-diphenyl-2-picrylhydrazyl) and anti-inflammatory activities. The EMd also exhibited promising anti-diarrheal effect in Swiss mice, while a negligible clotlysis activity was observed in clotted human blood. Additionally, the phytochemical screening of the crude plant extract revealed the presence of alkaloids, glycosides, flavonoids and reducing sugars. In conclusion, M. diplotricha may be a good source of antioxidant and anti-diarrheal agents. Further researches are recommended for the isolation and characterization of its phytochemicals.