This may be caused by genetic heart disease, enlarging of the shutoff's closure flaps or post-inflammatory modifications, such as those related to rheumatic cardiovascular disease. Often individuals who have troubles with the valve that blood moves through as it leaves the heart have actually a raised risk of thoracic aortic aneurysm. This is generally true for individuals that were birthed with an aortic shutoff that has only 2 flaps instead of 3.

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