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I did Med-line searches, looked through various chemical data related books (i.e. the Merck Index and other publications), made many phone calls to chemists, spent hours on the internet, and was amazed to find so little real safety data on some of these materials.

Considering the fact that some creatine products contain fairly high amounts of these chemicals, the lack of solid safety data did not make me feel very comfortable. The major point of this is really the amount of creatine ingested in relation to the amount of contaminant present. It’s not that a compound has a small amount of some contaminant per se, but the levels of the contaminant is found in relation to how much of the product is consumed is the real question.

In the December issue of Health and Nutrition Breakthroughs (p12, 1997) Dr. Podell addressed the same concern regarding creatine as I have when he stated “…there is the potentially important issue of product purity. Given the high doses of creatine most people take, even a minute toxic impurity could have a dangerous effect. Unfortunately we cannot be sure of a manufacturers’ quality controls.”

As we all know, people don’t just take 500mg (1/2 a gram) of creatine, they take 10,000mg (10g), 20,000mg (20g), or even 30,000mg (30g) of creatine per day, so even a small amount of a contaminant (such as the dihydrotriazine) can add up quickly.

For example, one creatine product contained as much as 18,000 parts per million (PPM) of Dicyandiamide. If a person is taking in ten grams per day of creatine, that’s 180 mg of this chemical a day. If you are taking in 30g a day of creatine-as is often the case during the loading phase-you would be getting a whopping 540mg a day of dicyandiamide!